Physical activity as a protective factor for development of non-alcoholic fatty liver in men.

OBJECTIVE: To determine the impact of physical activity on the prevalence of fatty liver, metabolic and cardiovascular disease in adult men. METHODS: This study evaluated 1,399 men (40.7±8.18 years) with body mass index of 26.7kg/m2 (±3.4) who participated in the Protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. We conducted tests of serum blood glucose, total cholesterol, LDL, HDL, triglycerides, reactive c-protein, aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase. The statistical analysis comprised in the comparison of mean and standard deviation. The analysis of variance was based in two paths of two way ANOVA, Student's t-test, Mann Whitney U test, Wald test and χ2. We considered a significance level at p<0.05 and correlation of univariate Poison with 95% confidence interval. RESULTS: Fatty liver was diagnosed in 37.0% of the sample. Triglyceride levels of active men with fatty liver were 148.2±77.6mg/dL while inactive men with fatty liver had 173.4±15.6mg/dL. The remaining serum levels were normal. Inactive individuals showed higher values than active. In addition, inactive individuals have 10.68 times higher risk of developing fatty liver compared with active. CONCLUSION: Physical activity improves metabolic parameters such as triglycerides, weight control, HDL, which interfere in the development of fatty liver. Physically active individuals had lower fatty liver prevalence regardless of values of body composition and lipid profile, leading the conclusion that physical activity has a protective role against development of fatty liver.

Physical activity as a protective factor for development of non-alcoholic fatty liver in men / Atividade física como fator de proteção para o desenvolvimento de esteatose hepática não alcoólica em homens / Atividade física como fator de proteção para o desenvolvimento de esteatose hepática não alcoólica em homens

Objective To determine the impact of physical activity on the prevalence of fatty liver, metabolic and cardiovascular disease in adult men. Methods This study evaluated 1,399 men (40.7±8.18 years) with body mass index of 26.7kg/m2 (±3.4) who participated in the Protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. We conducted tests of serum blood glucose, total cholesterol, LDL, HDL, triglycerides, reactive c-protein, aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase. The statistical analysis comprised in the comparison of mean and standard deviation. The analysis of variance was based in two paths of two way ANOVA, Student’s t-test, Mann Whitney U test, Wald test and χ2. We considered a significance level at p<0.05 and correlation of univariate Poison with 95% confidence interval. Results Fatty liver was diagnosed in 37.0% of the sample. Triglyceride levels of active men with fatty liver were 148.2±77.6mg/dL while inactive men with fatty liver had 173.4±15.6mg/dL. The remaining serum levels were normal. Inactive individuals showed higher values than active. In addition, inactive individuals have 10.68 times higher risk of developing fatty liver compared with active. Conclusion Physical activity improves metabolic parameters such as triglycerides, weight control, HDL, which interfere in the development of fatty liver. Physically active individuals had lower fatty liver prevalence regardless of values of body composition and lipid profile, leading the conclusion that physical activity has a protective role against development of fatty liver. .

Objetivo Determinar o impacto do nível de atividade física na prevalência de esteatose hepática, perfil metabólico e comportamento cardiovascular em homens adultos. Métodos Foram avaliados 1.399 homens (40,7±8,18 anos) com índice massa corporal de 26,7kg/m2 (±3,4) pelo protocolo da Revisão Continuada de Saúde do Hospital Israelita Albert Einstein entre janeiro a outubro de 2011. Foram realizadas análise séricas de glicose sanguínea, colesterol total e séries, triglicerídeos, PCR, ALT, AST e Gama GT. A análise estatística utilizada consistiu na comparação de média e desvio padrão. A análise de variância de dois caminhos ANOVA two way, teste t de Student, teste U Mann Whitney, teste de Wald e teste χ2, sendo o nível de significância p<0,05 e correlação univariada de Poison, com intervalo de confiança de 95%. Resultados Os resultados demonstraram que 37,0% da amostra apresentou diagnóstico de esteatose hepática. Homens ativos com esteatose hepática apresentaram níveis de triglicerídeos de 148,2±77,6mg/dL enquanto os inativos com esteatose hepática apresentaram 173,4±15,6mg/dL. Os demais níveis séricos apresentaram-se dentro dos padrões considerados saudáveis, porém os inativos apresentaram todos os valores superiores, em relação aos ativos. Apontou-se que indivíduos inativos apresentam 10,68 vezes maior risco em desenvolver esteatose hepática em relação aos ativos. Conclusão A atividade física melhora os indicadores metabólicos, como triglicérides, controle de peso, HDL, que interferem no desenvolvimento de esteatose hepática, mostrando que indivíduos fisicamente ativos apresentaram menor prevalência de esteatose hepática independentemente dos valores de composição corporal e perfil lipídico, concluindo que a atividade física apresenta papel protetor no desenvolvimento de esteatose hepática. .